January 25, 2010

The Cost Burden of Disease: U.S. and Michigan

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CHRT Issue Brief January 2010

There may be no broad consensus on the impact of recent health reform proposals on the growth of health care costs in the U.S., but few would dispute that rising health care costs are a threat to the U.S. economy, the health system, and the health and financial well-being of families and individuals in the United States. As we collectively seek ways to address the crisis of rising costs—as part of overall health reform or through regional, state, or local approaches—we must understand the factors that drive health care costs and where opportunities exist to affect those drivers.

In our December 2009 issue brief on health care spending, we looked at spending in the U.S. and Michigan by country, state, and payer to understand the scale and rate of growth in health care spending in the U.S., among states, and by public and private payers.

In this issue brief we present data that reveal the cost burden of disease: the most common reasons for hospitalization, the most expensive conditions, the costliest procedures, the costliest and most frequently prescribed prescription drugs. We also look at gender differences between men and women in the top ten diagnoses or each population at hospital discharge.

This issue brief on disease burden and the December 2009 issue brief on overall costs are part of a larger report on health care costs CHRT will publish in 2010, designed to stimulate thinking and further analysis about opportunities for change in health policy, medical practice—even personal health choices—that could lead to more effective and efficient overall health care spending.

Most Common Reasons for Hospitalization, U.S. and Michigan, 20071

Diagnosis at Discharge

In 2007, there were almost 40 million discharges from the hospital in the U.S. and 1.3 million in Michigan. The ten most common inpatient diagnoses in the U.S. and in Michigan accounted for nearly one-third of all inpatient discharges (31.6 percent U.S., 31.4 percent in Michigan). Of these, the most common reason for hospitalization was infant birth (newborns), which accounted for 11.5 percent of all hospital discharges.

Aside from childbirth-related diagnoses, these data show that cardiovascular disease was the most common reason for hospitalization in 2007. Nationally, four of the top ten diagnoses related to cardiovascular disease (coronary atherosclerosis, congestive heart failure, chest pain, and cardiac dysrhythmias); in Michigan, three of the top ten (coronary atherosclerosis, congestive heart failure, and cardiac dysrhythmias).

Mental health disorders were also in the top ten diagnoses in both Michigan and nationally, accounting for approximately two percent of all discharges from the hospital in the U.S. and Michigan.

Figure IB2.1: Top 10 Most Frequent Hospital Discharges by Diagnosis, U.S., 2007
United States
RankPrincipal DiagnosisTotal no. of discharges% of total no. of discharges
1 Liveborn (newborn infant) 4,542,685 11.5%
2 Pneumonia (except that caused by tuberculosis and sexually transmitted diseases) 1,171,546 3.0%
3 Congestive heart failure, nonhypertensive 1,024,903 2.6%
4 Coronary atherosclerosis (coronary artery disease) 963,903 2.4%
5 Trauma to perineum and vulva 867,786 2.2%
6 Osteoarthritis (degenerative joint disease) 814,934 2.1%
7 Other complications of birth, puerperium affecting management of the mother (complications of childbirth) 810,430 2.1%
8 Nonspecific chest pain 788,447 2.0%
9 Mood disorders (depression and bipolar disorder) 774,256 2.0%
10 Cardiac dysrhythmias (irregular heartbeat) 731,468 1.9%
Source: Healthcare Cost & Utilization Project (HCUP)
Figure IB2.2: Top 10 Most Frequent Hospital Discharges by Diagnosis, Michigan, 2007
Michigan
RankPrincipal DiagnosisTotal no. of discharges% of total no. of discharges
1 Liveborn (newborn infant) 122,272 9.5%
2 Congestive heart failure, nonhypertensive 37,791 2.9%
3 Pneumonia (except that caused by tuberculosis and sexually transmitted diseases) 37,333 2.9%
4 Coronary atherosclerosis (coronary artery disease) 37,289 2.9%
5 Osteoarthritis (degenerative joint disease) 33,531 2.6%
6 Septicemia (except in labor) 28,878 2.2%
7 Mood disorders (depression and bipolar disorder) 28,111 2.2%
8 Cardiac dysrhythmias (irregular heartbeat) 27,258 2.1%
9 Spondylosis, intervertebral disc disorders, other back problems (disorders of intervertebral discs and bones in spinal column) 27,011 2.1%
10 Complication of device, implant or graft 24,992 1.9%
Source: Healthcare Cost & Utilization Project (HCUP)

Gender Differences

Excluding childbirth-related diagnoses, most diagnoses were common to both males and females.

Overall, while heart-related diagnoses were common among both men and women, they were more frequent for men. Four heart-related diagnoses (coronary atherosclerosis, congestive heart failure, non-specific chest pain, and cardiac dysrhythmias) were among the ten most common principal diagnoses for male hospitalizations. Congestive heart failure and coronary atherosclerosis were among the ten most common among females.

Heart attacks (acute myocardial infarctions) ranked as the fifth most common discharge diagnosis among males, but were not among the top ten discharge diagnoses for females (rank for women was 25th).

Osteoarthritis (degenerative joint disease) was responsible for many more hospitalizations for females (498,199 discharges in the U.S.; 20,528 in Michigan) than for males (314,000 discharges in the U.S.; 13,002 in Michigan).

In the U.S. and in Michigan, women accounted for 57 percent of discharges for mood disorders, and men accounted for 43 percent.

In Michigan, mood disorders ranked seventh for females but was not among the top ten discharge diagnoses for males2.

Figure IB2.3a: Top 10 Most Frequent Hospital Discharges by Diagnosis, Michigan Males
Male—Michigan
RankPrincipal DiagnosisTotal discharges% of total discharges
1 Liveborn 62,896 11.7%
2 Coronary atherosclerosis 22,992 4.3%
3 Congestive heart failure, nonhypertensive 18,204 3.4%
4 Pneumonia (except that caused by tuberculosis and sexually transmitted diseases) 18,024 3.3%
5 Acute myocardial infarction 14,211 2.6%
6 Cardiac dysrhythmias 13,473 2.5%
7 Septicemia (except in labor) 13,326 2.5%
8 Osteoarthritis 13,002 2.4%
9 Spondylosis, intervertebral disc disorders, other back problems 12,875 2.4%
10 Complication of device, implant or graft 12,615 2.3%
Source: Healthcare Cost & Utilization Project (HCUP)
Figure IB2.3b: Top 10 Most Frequent Hospital Discharges by Diagnosis, Michigan Females
Female—Michigan
RankPrincipal DiagnosisTotal discharges% of total discharges
1 Liveborn 59,312 7.9%
2 Trauma to perineum and vulva 22,089 3.0%
3 Other complications of birth, puerperium affecting management of the mother 22,060 2.9%
4 Osteoarthritis 20,528 2.7%
5 Congestive heart failure, nonhypertensive 19,586 2.6%
6 Pneumonia (except that caused by tuberculosis and sexually transmitted diseases) 19,309 2.6%
7 Mood disorders 15,907 2.1%
8 Septicemia (except in labor) 15,551 2.1%
9 Other complications of pregnancy 14,604 2.0%
10 Coronary atherosclerosis 14,297 1.9%
Source: Healthcare Cost & Utilization Project (HCUP)

1 Facts and Figures 2007 Healthcare Cost and Utilization Project (HCUP). September 2009. Agency for Healthcare Research and Quality, Rockville, MD.

2 The rank for men was 11th.

Spending for Hospitalizations, U.S. and Michigan, 2007

Per Discharge Spending—Highest Charges per Discharge by Diagnosis3

Graphic showing discharge costs are 14x higher for premature and low birth weight infants compared to healthy infants

One important determinant of health care spending is the intensity of services provided during a hospital stay, often reflected in the charges per hospital discharge.

Conditions treated with more expensive technology or requiring intensive care—such as spinal cord injuries, heart valve disorders, cardiac and circulatory disorders, and leukemia—were among the top ten most costly diagnoses per stay in the U.S. and Michigan.

Nine of the top ten most costly diagnoses per hospital stay were the same for the U.S. and Michigan. However, in Michigan charges were consistently lower per hospitalization for all top diagnoses.

Among the most costly diagnoses per hospital stay in 2007 were those related to newborns. The average charge per discharge for premature birth and low birth weight was $119,389 in the U.S. and $102,103 in Michigan. This is approximately 14 times higher than the average charge of $7,182 per discharge for a healthy infant birth in Michigan.

Figure IB2.4: Top 10 Charges Per Discharge by Diagnosis, U.S., 20074
United States
RankPrincipal DiagnosisCharges, $ (mean)Total Number of Discharges
1 Infant respiratory distress syndrome $138,224 11,399
2 Spinal cord injury $126,060 13,226
3 Short gestation, low birth weight, and fetal growth retardation (premature birth and low birth weight) $119,389 24,904
4 Heart valve disorders $116,751 90,667
5 Leukemias $114,488 43,544
6 Cardiac and circulatory congenital anomalies $101,412 39,532
7 Other central nervous system infection and poliomyelitis $87,702 8,557
8 Aortic, peripheral, and visceral artery aneurysms (ballooning or rupture of an artery) $83,897 84,852
9 Hodgkin's disease $82,435 5,597
10 Intrauterine hypoxia and birth asphyxia (lack of oxygen to baby in uterus or during birth) $74,942 929
Source: Healthcare Cost & Utilization Project (HCUP)
Figure IB2.5: Top 10 Charges Per Discharge by Diagnosis, Michigan, 2007
Michigan
RankPrincipal DiagnosisCharges, $ (mean)Total Number of Discharges
1 Short gestation, low birth weight, and fetal growth retardation (premature birth and low birth weight) $102,103 465
2 Infant respiratory distress syndrome $99,247 246
3 Spinal cord injury $95,887 434
4 Cardiac and circulatory congenital anomalies $93,128 1,515
5 Heart valve disorders $88,630 3,034
6 Leukemias $87,346 1,386
7 Intrauterine hypoxia and birth asphyxia (lack of oxygen to baby in uterus or during birth) $78,682 29
8 Immunity disorders $75,969 56
9 Aortic, peripheral, and visceral artery aneurysms (ballooning or rupture of an artery) $72,033 3,366
10 Other central nervous system infection and poliomyelitis $71,254 323
Source: Healthcare Cost & Utilization Project (HCUP)

Total Spending—Highest Total Costs by Diagnosis

Heart disease accounted for the highest total spending of any condition—over $143 billion nationally and $4.2 billion in Michigan.

Among the most common reasons for hospitalization are conditions that are defined as “potentially preventable”—that is, those that may be preventable with high quality primary and preventive care. Thus, higher rates of “potentially preventable hospitalizations”—including hospitalizations for heart failure and pneumonia—highlight specific areas where targeted improvements can be made.

Additionally, conditions such as septicemia and back disorders are viewed as at least partially preventable, and are also among the top ten in spending in the U.S. and Michigan. Total hospital spending on back disorders alone was almost $26 billion in the U.S. and $819 million in Michigan.

Many who have coronary artery disease also have diabetes. Recent research estimates that medical expenditures for people with diabetes are more than twice as high as those without diabetes. In fact, spending on diabetes and associated complications accounted for approximately one in ten health care dollars spent in the U.S. in 2007.5

Figure IB2.6: Top 10 Total Charges by Diagnosis, U.S., 20074
United States
RankPrincipal DiagnosisTotal Number of DischargesCharges, $ (mean)Aggregate Charges “The National Bill” ($ Billions)
1 Coronary atherosclerosis (hardening of the heart arteries and other heart disease) 963,903 $46,598 $44.9
2 Liveborn 4,542,685 $8,733 $39.7
3 Septicemia (blood infection, except in labor) 675,391 $57,543 $38.9
4 Acute myocardial infarction (heart attack) 624,936 $54,393 $33.8
5 Osteoarthritis (degenerative joint disease) 814,934 $41,210 $33.6
6 Congestive heart failure, nonhypertensive 1,024,903 $31,600 $32.3
7 Complication of device, implant or graft 623,890 $49,052 $30.6
8 Pneumonia (except that caused by tuberculosis and sexually transmitted diseases) 1,171,546 $25,478 $30.0
9 Spondylosis (back problems, disorders of intervertebral discs and bones in spinal column) 633,742 $40,762 $25.8
10 Respiratory failure, insufficiency, arrest (adult) 385,832 $62,158 $23.9
Source: Healthcare Cost & Utilization Project (HCUP)
Figure IB2.7: Top 10 Total Charges by Diagnosis, Michigan, 2007
Michigan
RankPrincipal DiagnosisTotal Number of DischargesCharges, $ (mean)Aggregate Charges ($ Millions)
1 Coronary atherosclerosis (hardening of the heart arteries and other heart disease) 37,289 $37,640 $1,404
2 Septicemia (blood infection, except in labor) 28,878 $39,783 $1,149
3 Osteoarthritis 33,531 $30,596 $1,026
4 Acute myocardial infarction (heart attack) 24,606 $41,614 $1,024
5 Complication of device, implant or graft 24,992 $39,834 $996
6 Congestive heart failure, nonhypertensive 37,791 $24,420 $923
7 Liveborn 122,272 $7,182 $878
8 Spondylosis (back problems, disorders of intervertebral discs and bones in spinal column) 27,011 $30,307 $819
9 Respiratory failure, insufficiency, arrest (adult) 14,755 $53,016 $782
10 Pneumonia (except that caused by tuberculosis and sexually transmitted diseases) 37,333 $18,324 $684
Source: Healthcare Cost & Utilization Project (HCUP)

Total Spending—Highest Total Costs by Procedure

The four highest-cost inpatient procedures were the same for the U.S. and Michigan:

  1. respiratory intubation and mechanical ventilation
  2. percutaneous coronary angioplasty
  3. spinal fusion
  4. arthroplasty of the knee (knee replacement)

Nine of the top ten highest total cost inpatient procedures were the same for the U.S. and for Michigan.

Figure IB2.8: Top 10 Total Charges by Procedure (in Billions), U.S., 2007
United States
RankPrincipal DiagnosisTotal Number of DischargesCharges, $ (mean)Aggregate Charges “The National Bill” ($ Billions)
1 Respiratory intubation and mechanical ventilation 754,168 $73,415 $55.0
2 Percutaneous coronary angioplasty (use of a balloon-tipped catheter to enlarge a narrowed artery) 668,036 $51,460 $34.4
3 Spinal fusion 350,754 $74,672 $26.2
4 Arthroplasty, knee 605,176 $42,159 $25.5
5 Other vascular catheterization, not heart 558,138 $45,284 $25.2
6 Insertion, revision, replacement, removal of cardiac pacemaker or cardioverter/ defibrillator 329,904 $75,834 $25.0
7 Cesarean section 1,479,640 $15,872 $23.5
8 Other operating room procedures on vessels other than head and neck 305,064 $74,524 $22.3
9 Coronary artery bypass graft (CABG, procedure to restore blood supply to the heart muscle) 198,669 $112,377 $22.3
10 Hip replacement, total and partial 402,060 $47,757 $19.2
Source: Healthcare Cost & Utilization Project (HCUP)
Figure IB2.9: Top 10 Total Charges by Procedure (in Millions), Michigan, 2007
Michigan
RankPrincipal DiagnosisTotal Number of DischargesCharges, $ (mean)Aggregate Charges ($ Millions)
1 Respiratory intubation and mechanical ventilation 24,814 $57,406 $1,424.5
2 Percutaneous coronary angioplasty (use of a balloon-tipped catheter to enlarge a narrowed artery) 29,316 $40,694 $1,193.0
3 Spinal fusion 16,094 $51,951 $836.1
4 Arthroplasty, knee 25,100 $31,074 $780.0
5 Other operating room procedures on vessels other than head and neck 13,190 $57,065 $752.7
6 Insertion, revision, replacement, removal of cardiac pacemaker or cardioverter/ defibrillator 10,586 $70,408 $745.3
7 Other vascular catheterization, not heart 21,493 $32,403 $696.4
8 Coronary artery bypass graft (CABG, procedure to restore blood supply to the heart muscle) 7,558 $88,732 $670.6
9 Hip replacement, total and partial 15,369 $35,461 $545.0
10 Upper gastrointestinal endoscopy, biopsy 24,191 $22,137 $535.5
Source: Healthcare Cost & Utilization Project (HCUP)

3 Because of available data, information included in this report related to hospital spending is based on charges rather than actual payments by payers and consumers. Charges can be significantly higher than payments but the relative rankings should not be significantly affected.

4 Hospital charges are the amounts usually seen by a patient when they receive their hospital bill. Charges seldom represent what is actually paid for hospital stays because of negotiated discounts, but they do offer a useful benchmark for comparing the relative costliness of conditions.

5 Economic Costs of Diabetes in the U.S. in 2007, American Diabetes Association, 2008.

Prescription drugs, U.S. and Michigan, 2008

Top Drugs by Number of Dispensed Prescriptions

Drug spending represented approximately 20 percent of total spending for health care in the U.S and in Michigan ($291 billion and $11 billion respectively).

The most commonly prescribed drug in the U.S. and Michigan was the generic equivalent for Vicodin, a prescription narcotic pain medication. Generic Vicodin accounted for more than 124

million prescriptions in the U.S. and 5.1 million prescriptions in Michigan. While it is difficult to separate out the costs of pain management from other treatment costs, we know that drugs like Vicodin are associated with some of the high cost procedures listed in Figure IB2.8.

The second- and third-most prescribed medications in the U.S. and Michigan were ACE inhibitor Lisinopril and cholesterol-lowering Simvastatin (brand name Zocor).

Figure IB2.10a: Top drug names by number of dispensed prescriptions, U.S., 2008
United States
RankDrug NameTotal Rxs (millions)
1 Hydrocodone/acetaminophen 124.0
2 Lisinopril 75.5
3 Simvastatin 66.7
4 Levothyroxine Sod 61.4
5 Lipitor 57.9
6 Azithromycin 51.1
7 Amoxicillin 50.9
8 Hydrochlorothiazid 47.5
9 Amlodipine Besy 44.1
10 Furosemide 43.4
11 Metformin Hcl 41.6
12 Alprazolam 41.5
13 Atenolol 40.8
14 Metoprolol Succin 39.7
15 Omeprazole 35.1
Total U.S. Prescription Market3,807.2
Source: IMS National Sales Perspectives™
Figure IB2.10b: Top drug names by number of dispensed prescriptions, Michigan, 2008
Michigan
RankDrug NameTotal Rxs (millions)
1 Hydrocodone/acetaminophen 5.16
2 Lisinopril 2.37
3 Simvastatin 2.19
4 Amoxicillin 2.15
5 Levothyroxine 1.99
6 Ibuprofen (prescription) 1.64
7 Alprazolam 1.59
8 Azithromycin 1.58
9 Omeprazole 1.36
10 Metformin HCL 1.34
11 Atenolol 1.27
12 Hydrochlorothiazide 1.19
13 Furosemide 1.10
14 Lipitor 1.08
15 Amlodipine 1.06
Total for Michigan116.4
Source: IMS National Sales Perspectives™